This verse also assumes the backdrop of remembered compassion in 63:7–9. Inference: the rebellion is framed as a response to prior kindness, making the rupture more serious and explaining why present distress feels like the opposite of earlier rescue.

Where interpretation differs

Who are “they/them”? Some read the pronouns as the whole nation in a corporate sense (Israel/Judah as a community). Others stress that the language may target the rebel portion within the people, while the larger prayer later speaks for the community as it seeks restoration.

What does “his holy Spirit” mean here? Many readers take “holy Spirit” as God’s own active presence among the people (not merely a mood). Others read it as a poetic way of speaking about God’s holiness and nearness without specifying a distinct personal agent. The verse itself focuses on relational injury more than on defining the Spirit’s identity.

What kind of “fighting” is intended? Some take it primarily as historical events (defeat, invasion, exile) understood theologically: God opposed them in real-world outcomes. Others treat “fought” more broadly as God working against their plans and security in many forms of resistance, not only battlefield conflict.

Why the disagreement exists The verse uses compact, relational language—“turned,” “enemy,” “fought”—without spelling out the mechanics (how God “turns”), the boundaries of the group (“they”), or the precise referent of “holy Spirit.” Also, Isaiah 63 sits in a remembrance-and-appeal section, so readers weigh how much is historical description versus prayerful interpretation of suffering.

What this passage clearly contributes It gives a direct cause-and-effect explanation for experienced alienation: rebellion leads to a real rupture, described as grieving God’s holy Spirit, and that rupture can be experienced as God actively opposing his people. It also portrays sin as personally and relationally damaging, not only as rule-breaking. Finally, it sets up the logic of the wider section (63:11–19): if God once saved, why does it now feel like he fights against them—unless something in the relationship has been reversed.