Shared ground
Isaiah 51:21–23 speaks to Jerusalem in a condition so crushed that it is compared to drunkenness—yet “not with wine.” The text presents this as the effect of overwhelming calamity, not ordinary intoxication (explicit textual claim).
The Lord identifies himself as their ruler and God, and as the one who “pleads the cause” of his people (explicit textual claim). The central image is the “cup of staggering,” also called “the bowl of the cup of my wrath.” God says he has removed that cup from their hand and that they will not drink it again (explicit textual claim). Then God says he will place it into the hand of “those who afflict you,” the ones who humiliated Jerusalem and treated her like a road to walk on (explicit textual claim).
Where interpretation differs
Some readers take the “cup” language to refer mainly to a specific historical disaster (the fall of Jerusalem and its aftermath). Others read it more broadly as a recurring pattern: God allows intense suffering, then reverses it, and makes oppressors answer for what they did. Both fit the passage’s plain imagery; the difference is how narrowly “those who afflict you” is defined (inference built on the text’s wording).
Another smaller question is whether “you shall no more drink it again” is a fully absolute promise in every sense, or a strong way of saying this particular phase of wrath and collapse is ending. The verse is phrased with finality, but interpreters differ on whether prophetic speech always intends that kind of absolute scope (inference about rhetorical force).
Why the disagreement exists
The passage uses a poetic metaphor (“cup”) that can point to a concrete event, a sustained condition, or both. Also, the text does not name the oppressors here, so readers decide whether the language is mainly about one empire in one moment or about oppressors more generally.
What this passage clearly contributes
This text contributes a clear picture of divine reversal: suffering is not presented as random fate, but as an assigned “cup” that God can remove and reassign. It also portrays God’s relationship to his people in legal-defense terms (“pleads the cause”), meaning the reversal is framed as justice for the abused, not merely relief. Finally, it links oppression with humiliation (“bow down…that we may go over”), showing that the wrong addressed is not only military defeat but also dehumanizing treatment.